Xiaohong Tan

Xiaohong Tan, PhD

Assistant Professor
Bowling Green State University 
Department of Chemistry

Associate Editor of Frontiers in Molecular Biosciences: Molecular Recognition 


Dr. Tan

PhD., Nanyang Technological University, Singapore
M.S., Sichuan University, China
B.A., Sichuan University, China

Email: tanx@bgsu.edu

Office: Room 211, Physical Sciences Laboratory Building,
Bowling Green State University,
Bowling Green, Ohio, 43403

Phone: 419-372-3229

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Recent Work

Our research activities are mainly in the areas of nucleic acid biochemistry, protein biochemistry, peptide/protein chemistry, bioanalytical chemistry, chemical biology, and bioengineering. Our research aim is to develop next-generation platform for disease diagnostics and therapy. To realize this aim, we are interested in playing with Nature's building blocks, peptide, protein, DNA and RNA.

PD-L1/PD-1 interaction

PD-L1 are constitutively expressed or overexpressed on different types of human tumor cells.
Since cancer cells use the PD-L1 to help them evade immune attack, inhibitors that target PD-L1 can block this binding and boost the immune response against cancer cells. Our group is interested in developing biosensors for PD-L1 detection.


We have discovered DNA aptamers which can universally inhibit interactions between human ACE2 and spike proteins of various SARS-CoV-2 variants. We also reported the first anti-S2 aptamer.

Other Biosensors

We also work on discovering aptamers against small molecules such as Ni-NTA etc.